Knight's interests include the origin and development of complex societies, the archaeology of social organization and religion, and archaeological approaches to iconography. His work particularly concerns the late prehistoric, early historic, and colonial periods of the Southeast and Caribbean, with emphasis on ethnohistorical reconstruction. Knight believes that graduates of a course of study in anthropological archaeology should be at home in the field, in the laboratory, in the classroom, and in the museum. He views his role in graduate training as primarily one of developing the student's research competence, both through guiding their mastery of published scholarship and through providing opportunities for practical experience. He serves with the Museum of Natural History as Curator of Southeastern Archaeology.