Abstract: This study was conducted to assess the relationship between intakes of dietary goitrogens and the prevalence of goiter among a select group of pregnant women along the coast of Galle District in Southwestern Sri Lanka. Fifty-nine cases and 31 controls, recruited from antenatal clinics and from the field, participated in the study. A single 24 hour dietary recall for each subject was analyzed for intake of energy. A food frequency questionnaire was used to measure usual intakes of seafood and goitrogen containing foods. The relationship between goiter status and high (21 serving/d) versus low (< 1 serving/d) consumption frequencies of goitrogen containing foods and seafood was assessed by logistic regression. There was no significant relationship between goiter status and frequency of goitrogen intake (P = 0.08, 0.R = 0.33, C.I. = 0.09-1.17). There were no significant differences between cases and controls in intake of energy and frequency of seafood intake, or the 1- content of drinking water. The results of this study suggest that goiter in this population is not associated with excessive goitrogen consumption.